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Other Products

R&D Pipeline - Partnering Opportunities

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Immunotherapy

TTX-siPDL1
TTX-siPDL1 is a therapeutic candidate in development with TransCode to target PD-1/PD-L1. As traditional checkpoint inhibitors simply block PD-1/PD-L1 from binding each other, they may be ineffective in many cancers, including pancreatic cancer. However, TTX-siPDL1 employs an RNAi approach with the intention of preventing the synthesis of PD-L1 altogether instead of blocking its function.

As a result of successful animal studies, TTX-siPDL1 has received Orphan Designation Status from FDA for pancreatic cancer.
Learn more about TTX-siPDL1:
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TTX-RIGA
Immunotherapy represents a powerful alternative to traditional clinical treatments for cancer. Recent developments in the use of Pattern Recognition Receptors, or PRRs, specifically retinoic acid-inducible gene I-like receptors (RIG-I), aim to harness the innate power of the immune system for anti-cancer therapy. TTX-RIGA is in development to target cancer via the RIG-I signaling pathway. Delivery of TTX-RIGA combines with a tumor specific RNA inside tumor cells to produce  a potent agonist of the RIG-I signaling pathway.

RIG-I engagement has been shown to promote tumor cell death, and to activate the innate and adaptive immune systems. These factors suggest it could be an attractive therapeutic approach in oncology.

​Learn more about TTX-RIGA:
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Gene Editing

  • TTX-CRISPR (BEC) - Collaboration with Akribion (spin-out of BRAIN Biotech)
  • ​TTX-CRISPR

Radiotherapy

​64Cu-TTX-MC138
The use of radioisotopes is a (re)emerging approach for many drug development companies in the treatment of cancer. TransCode believes our TTX has the potential for efficient localized penetration of radioisotopes inside tumor cells. 64Cu-TTX-MC138 has potential benefits that include:
  • PK profile that minimizes off-target exposure, maximizes high tumor uptake
  • Achieves localization, penetration, and persistence across tumor histologies while maximizing systemic clearance
  • Deeper tumor penetration to enable more homogeneous irradiation of tumor mass
  • Achieving the above enables use of off-target toxicity reducing short-range alpha emitters
In pre-clinical studies, delivery of 64Cu-TTX-MC138 to metastatic sites has already been demonstrated; a first-in-human microdosing study is anticipated in 1Q 2023. 

Learn more about 64Cu-TTX-MC138:
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Cancer Vaccines

  • TTX-mRNA, a messenger RNA-based platform for the development of cancer vaccines that activate cytotoxic immune responses against tumor cells.

Diagnostics

miRNA detection
We are also studying approaches for early cancer detection.
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Other molecular therapeutics

Target binding scaffolds - cytosolic delivery or proteins including nanobodies 
(stay tuned for future developments)

TransCode has executed an exclusive option agreement with Massachusetts General Hospital (MGH), for 64Cu-TTX-MC138, under which TransCode has the right to negotiate an exclusive license for this assets.
TTX is an investigational platform encompassing therapeutic candidates (including TTX-MC138) and diagnostics which remain in development. Their safety and efficacy have not yet been evaluated by the FDA or any other regulatory agency.

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  • Home
    • Mission
    • Clinical Trials
  • About
    • Metastatic Disease
    • Lead Candidate
    • Science
    • Pipeline >
      • Delivery Platform
      • Other Products
    • Leadership
  • Publications
  • Investors
  • Partnering